Deep Residual Policy Reinforcement Learning as a Corrective Term in Process Control for Alarm Reduction: A Preliminary Report

Conventional process controllers (such as proportional integral derivative controllers and model predictive controllers) are simple and effective once they have been calibrated for a given system. However, it is difficult and costly to re-tune these controllers if the system deviates from its normal conditions and starts to deteriorate. Recently, reinforcement learning has shown a significant improvement in learning process control policies through direct interaction with a system, without the need of a process model or the system characteristics, as it learns the optimal control by interacting with the environment directly. However, developing such a black-box system is a challenge when the system is complex and it may not be possible to capture the complete dynamics of the system with just a single reinforcement learning agent. Therefore, in this paper, we propose a simple architecture that does not replace the conventional proportional integral derivative controllers but instead augments the control input to the system with a reinforcement learning agent. The agent adds a correction factor to the output provided by the conventional controller to maintain optimal process control even when the system is not operating under its normal condition

Interpretable Input-Output Hidden Markov Model-Based Deep Reinforcement Learning for the Predictive Maintenance of Turbofan Engines

An open research question in deep reinforcement learning is how to focus the policy learning of key decisions within a sparse domain. This paper emphasizes on combining the advantages of input-output hidden Markov models and reinforcement learning. We propose a novel hierarchical modeling methodology that, at a high level, detects and interprets the root cause of a failure as well as the health degradation of the turbofan engine, while at a low level, provides the optimal replacement policy. This approach outperforms baseline deep reinforcement learning (DRL) models and has performance comparable to that of a state-of-the-art reinforcement learning system while being more interpretable

Specialized Deep Residual Policy Safe Reinforcement Learning-Based Controller for Complex and Continuous State-Action Spaces

Traditional controllers have limitations as they rely on prior knowledge about the physics of the problem, require modeling of dynamics, and struggle to adapt to abnormal situations. Deep reinforcement learning has the potential to address these problems by learning optimal control policies through exploration in an environment. For safety-critical environments, it is impractical to explore randomly, and replacing conventional controllers with black-box models is also undesirable. Also, it is expensive in continuous state and action spaces, unless the search space is constrained. To address these challenges we propose a specialized deep residual policy safe reinforcement learning with a cycle of learning approach adapted for complex and continuous state-action spaces. Residual policy learning allows learning a hybrid control architecture where the reinforcement learning agent acts in synchronous collaboration with the conventional controller. The cycle of learning initiates the policy through the expert trajectory and guides the exploration around it. Further, the specialization through the input-output hidden Markov model helps to optimize policy that lies within the region of interest (such as abnormality), where the reinforcement learning agent is required and is activated. The proposed solution is validated on the Tennessee Eastman process control

Hierarchical Framework for Interpretable and Probabilistic Model-Based Safe Reinforcement Learning

The difficulty of identifying the physical model of complex systems has led to exploring methods that do not rely on such complex modeling of the systems. Deep reinforcement learning has been the pioneer for solving this problem without the need for relying on the physical model of complex systems by just interacting with it. However, it uses a black-box learning approach that makes it difficult to be applied within real-world and safety-critical systems without providing explanations of the actions derived by the model. Furthermore, an open research question in deep reinforcement learning is how to focus the policy learning of critical decisions within a sparse domain. This paper proposes a novel approach for the use of deep reinforcement learning in safety-critical systems. It combines the advantages of probabilistic modeling and reinforcement learning with the added benefits of interpretability and works in collaboration and synchronization with conventional decision-making strategies. The BC-SRLA is activated in specific situations which are identified autonomously through the fused information of probabilistic model and reinforcement learning, such as abnormal conditions or when the system is near-to-failure. Further, it is initialized with a baseline policy using policy cloning to allow minimum interactions with the environment to address the challenges associated with using RL in safety-critical industries. The effectiveness of the BC-SRLA is demonstrated through a case study in maintenance applied to turbofan engines, where it shows superior performance to the prior art and other baselines.Comment: arXiv admin note: text overlap with arXiv:2206.1343

Dynamic Influence Diagram-Based Deep Reinforcement Learning Framework and Application for Decision Support for Operators in Control Rooms

In today’s complex industrial environment, operators are often faced with challenging situations that require quick and accurate decision-making. The human-machine interface (HMI) can display too much information, leading to information overload and potentially compromising the operator’s ability to respond effectively. To address this challenge, decision support models are needed to assist operators in identifying and responding to potential safety incidents. In this paper, we present an experiment to evaluate the effectiveness of a recommendation system in addressing the challenge of information overload. The case study focuses on a formaldehyde production simulator and examines the performance of an improved Human-Machine Interface (HMI) with the use of an AI-based recommendation system utilizing a dynamic influence diagram in conjunction with reinforcement learning. The preliminary results indicate the potential of these methods to aid operators in decision-making during challenging situations and enhance process safety in the industry

Fatty acid profiling and physiochemical characterization of Chlorella sorokiniana potentially used for biofuel production

Rising oil prices and climate change have resulted in more emphasis on research into renewable biofuels. In this study, different water samples were collected from local vicinities for the isolation of local isolates of microalgae to check their potential towards the production of biofuel by the addition of different chemical substrates. Five different concentrations of ascorbic acid and iron (III) chloride (0, 1, 2.5, 5 & 10 µM) are used as substrates. Microscopic analysis evaluated that samples belong to genus Chlorella and further molecular identification showed that the samples are C. sorokiniana. Among all the concentrations of ascorbic acid 2.5 µM is most effective against the C. sorokiniana strain 1 (Safari Wildlife Park, Lahore) and C. sorokiniana strain 2 (Bahria Town, Lahore) while C. sorokiniana Strain 3 (SukhChane Society, Lahore) responded at 2.5 & 5 µM in term of biomass production. FeCl3 (2.5 µM) is effective against C. sorokiniana strain 1 while the growth of C. sorokiniana strain 2 and C. sorokiniana Strain 3 is inhibited. Lipid content analysis showed that only the C. sorokiniana strain 1 shows effective results at 1 & 2.5 µM of ascorbic acid and FeCl3 , respectively. Those concentrations which give the significant results of lipid production were preceded for fatty acid profiling. Results indicate that the C. sorokiniana strain 1 can be considered as a source of alpha-linolenic acid; the basic constituent of biofuel production. In this study, it is concluded that C. sorokiniana strain 1 is useful for the production of environment friendly biofuel

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London